Oral Proton Pump Inhibitors

There is currently a lack of evidence to suggest superior clinical efficacy of one oral proton pump inhibitor over any other. Proton pump inhibitors display similar doseresponse relationships with similar potencies and efficacies at the equivalent dose. The decision to select one proton pump inhibitor over another is likely to be based on the agents’ licensed indication, patient tolerability and cost. Omeprazole and lansoprazole capsules, prescribed generically, for these reasons, are the Drugs of Choice across NHS Greater Glasgow. intragastric pH above 4 for a significantly higher mean percentage of the 24-h period. The clinical significance of these types of studies is unclear as it cannot be assumed that a quantitatively greater degree of suppression of intragastric pH translates into a demonstrable advantage in healing rates or resolution of symptoms in clinical practice.